Medical professionals can get a "simultaneous consult" about their patient's diagnosis using SimulConsult's diagnostic decision support software in three ways.

Individual medical professionals can register for a free Classic Phenome version. Using this version, they can enter patient findings into the software to get an initial differential diagnosis and suggestions about other useful findings, including tests. They can also send the Patient Summary output to radiology and genomic labs to improve communication, in lieu of a detailed note.

Health System Enterprise versions offer a choice between deep integration with the electronic health record (EHR) and a lighter integration. The deep integration improves documentation and communicating within a health system, and outputs include an editable note and structured data. Lighter integration using the EHR's resource links page offers IP-number based access and permissioning, but no further EHR integration.

Genomic labs can use the Genome-Phenome Analyzer version to combine a genome variant table with the phenotype data entered by the referring clinician (or the lab genetic counselor), thereby using the full power of genome and phenome to converge quickly on a diagnosis. An innovative measure of pertinence of genes focuses attention on the genes related to the clinical picture, even if more than one gene is involved. The Genome Report enables fast selection of diagnoses, genes and variants, and export to reporting platforms, including the prognosis table to answer the clinician and patient question "what should I expect".

The database used by the software has > 6,900 diagnoses, and is most complete for genetics, neurology and increasingly pediatric rheumatology. It includes the genes with convincing human disease phenotypes in OMIM and the diseases in GeneReviews. The information about diseases is entered by clinicians, referenced to the literature and peer-reviewed by experts. The computational software goes well beyond search to take into account pertinent negatives, temporal information, and cost of tests, information ignored in other diagnostic approaches. It transforms medical diagnosis by lowering costs, reducing errors, improving documentation and eliminating the medical diagnostic odysseys experienced by far too many patients and their families.